2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137119
    (±)5-iPF2α-VI
    		Control
    (±)5-iPF2α-VI (5-iso Prostaglandin F2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress.
    (±)5-iPF2α-VI
  • HY-106077A
    Meteneprost potassium
    Meteneprost (U 46785) potassium is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.
    Meteneprost potassium
  • HY-118599
    Prostaglandin F2α ethyl amide
    Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191).
    Prostaglandin F2α ethyl amide
  • HY-125626
    8-iso-15-keto Prostaglandin F2α
    		Agonist
    8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration.
    8-iso-15-keto Prostaglandin F2α
  • HY-107340
    Diftalone
    		Inhibitor
    Diftalone (Aladione) is an anti-inflammatory agent. Diftalone can be used for research of inflammatory disease, such as rheumatoid arthritis.
    Diftalone
  • HY-106206
    AL-6598
    		Agonist
    AL-6598 is a partial agonist of the DP and EP prostaglandin receptors. AL-6598 reduces intraocular pressure and is used in glaucoma research.
    AL-6598
  • HY-136696
    11-Deoxy-16,16-dimethyl-PGE2
    		Agonist
    11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress.
    11-Deoxy-16,16-dimethyl-PGE2
  • HY-139119
    Prostaglandin F2α dimethyl amide
    		Antagonist
    Prostaglandin F2α dimethyl amide is an antagonist for Prostaglandin F2α (HY-12956), which blocks 50% contraction on gerbilMeriones unguiculatus colon induced by PGF2α at 3.2 μg/mL.
    Prostaglandin F2α dimethyl amide
  • HY-110198
    ONO-8130
    		Antagonist
    ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research.
    ONO-8130
  • HY-14466
    GW 848687X
    		Antagonist
    GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.
    GW 848687X
  • HY-112533
    11-Deoxy-11-methylene PGD2
    11-Deoxy-11-methylene PGD2 (11d-11m-PGD2) is a chemically stable, isosteric analogue of Prostaglandin 2 in which the 11-keto group is replaced by an exocyclic methylene. 11-Deoxy-11-methylene PGD2 is significantly stimulating the storage of fats suppressed in the presence of Indomethacin.
    11-Deoxy-11-methylene PGD2
  • HY-158937
    15(R)-15-Methyl prostaglandin F2α methyl ester
    		Control
    15(R)-15-Methyl prostaglandin F2α methyl ester (15(R)-Methyl carboprost) (compound 15R) is a 15-methyl substituted prostaglandin analog, a member of the prostaglandin family, with potential biological activities in a variety of biological systems, but its specific activity mechanism and application details are not described in detail from the existing information.
    15(R)-15-Methyl prostaglandin F2α methyl ester
  • HY-79593S1
    MRE-269-d6
    		Agonist
    MRE-269-d6 is deuterium labeled MRE-269. MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
    MRE-269-d<sub>6</sub>
  • HY-108561
    L-670596
    		Antagonist
    L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069.
    L-670596
  • HY-113459S1
    13,14-Dihydro-15-keto Prostaglandin F2α-d4
    13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy.
    13,14-Dihydro-15-keto Prostaglandin F2α-d<sub>4</sub>
  • HY-114792
    15-Methylprostaglandin E1
    15-Methylprostaglandin E1 (15S-15-Methyl-PGE1) exhibits a positiv chronotropic effect, increases the heart rate and levels of nicardipine.
    15-Methylprostaglandin E1
  • HY-N7748A
    Epi-cryptoacetalide
    		Agonist
    Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities.
    Epi-cryptoacetalide
  • HY-116099
    ER-819762
    		Antagonist
    ER-819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor. ER-819762 can be used for rheumatoid arthritis research.
    ER-819762
  • HY-126115
    15(S)-Latanoprost
    		Inhibitor
    15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    15(S)-Latanoprost
  • HY-106066
    Dazmegrel
    		Inhibitor
    Dazmegrel (UK-38485) is a thromboxane synthetase inhibitor which inhibits Thromboxane A2 (TXA2) synthesis and exhibits antiplatelet vasodilator effects. Dazmegrel can be utilized in thrombosis research.
    Dazmegrel
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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