2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120197
    17-Phenyl trinor prostaglandin F2α methyl amide
    		Inhibitor
    17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding.
    17-Phenyl trinor prostaglandin F2α methyl amide
  • HY-120973A
    (S)-Butaprost free acid
    (S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor.
    (S)-Butaprost free acid
  • HY-165434
    Naxaprostene
    		Agonist
    Naxaprostene is a prostacyclin analogue. Naxaprostene was much more selective for IP receptors and tended towards partial agonism. Naxaprostene inhibits ADP-induced platelet aggregation. It has been shown to prevent rabbit carotid artery thrombosis.
    Naxaprostene
  • HY-118094
    8-iso Prostaglandin E1
    8-iso Prostaglandin E1 (Ovinonic acid; 8-iso-PGE1) is a spasmodic agent in canine pulmonary veins and can also cause vasodilation.
    8-iso Prostaglandin E1
  • HY-122499
    Ciprostene calcium
    Ciprostene calcium is a prostacyclin analogue.Ciprostene calcium inhibits adenosine diphosphate-induced platelet aggregation. Ciprostene calcium can be used for research of peripheral vascular disease.
    Ciprostene calcium
  • HY-110351
    BGC-20-1531 hydrochloride
    		Antagonist
    BGC 20-1531 (PGN 1531) hydrochloride is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC 20-1531 hydrochloride has the potential for the research of migraine headache.
    BGC-20-1531 hydrochloride
  • HY-125150
    AL-3138
    		Antagonist
    AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production.
    AL-3138
  • HY-B0195R
    Tranilast (Standard)
    		Inhibitor
    Tranilast (Standard) is the analytical standard of Tranilast. This product is intended for research and analytical applications. Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.
    Tranilast (Standard)
  • HY-156101
    Latanoprost amide
    		Control
    Latanoprost amide is a derivative of the F-prostaglandin (FP) receptor agonist Latanoprost (HY-B0577).
    Latanoprost amide
  • HY-176011
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester
    		Agonist
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a human prostaglandin FP receptor agonist. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma.
    17-Phenyl trinor prostaglandin F2α glycinamide methyl ester
  • HY-118681
    8-Iso-16-cyclohexyl-tetranor prostaglandin E2
    8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is an analog of Prostaglandin E2 (HY-101952).
    8-Iso-16-cyclohexyl-tetranor prostaglandin E2
  • HY-101606
    Etersalate
    		Inhibitor
    Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
    Etersalate
  • HY-19189
    Terbogrel
    		Antagonist
    Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC50s of about 10 nM.
    Terbogrel
  • HY-101602
    Aligeron
    		Antagonist
    Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
    Aligeron
  • HY-101692
    AZ-1355
    		98.19%
    AZ-1355 is an orally active and effctive lipid-lowering agent. AZ-1355 inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
    AZ-1355
  • HY-139063
    16-Phenoxy tetranor prostaglandin F2α
    16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.
    16-Phenoxy tetranor prostaglandin F2α
  • HY-124150
    BM567
    		Inhibitor
    BM567 is a sulfonylurea compound (compound 1), which exhibits antithrombogenic efficacy as thromboxane A2 receptor (TXR) antagonists and thromboxane A2 synthase (TXS) inhibitors, with IC50s of 1.1 and 12 nM, respectively.
    BM567
  • HY-116613
    FR-181877
    		Agonist
    FR-181877 (compound 4) is a non-prostaglandin PGI2 agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC50 value of 0.081 μM.
    FR-181877
  • HY-158550
    13(R),14(R)-epoxy Fluprostenol isopropyl ester
    		Control
    13(R),14(R)-epoxy Fluprostenol isopropyl ester is a Prostaglandin derivative.
    13(R),14(R)-epoxy Fluprostenol isopropyl ester
  • HY-137544
    16-Phenyl tetranor Prostaglandin F2α
    16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
    16-Phenyl tetranor Prostaglandin F2α
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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